Serving Kern County Since 1987
Imminohistochemical Stains

ANTIBODY: INTERPRETATION

  • AE1: Cytokeratin
  • AE3: Cytokeratin
  • BCL-2: Anti-apoptosis protein, B cell subset, follicular lymphoma
  • BCL-6: Germinal center B cell
  • CA19-9: Adenocarcinoma of pancreas, stomach
  • CA 125: Female reproductive tract, ovarian carcinoma
  • Calponin: Smooth muscle marker
  • Calretinin: Mesothelial marker
  • CD2: B cells and subset of NK - cell malignancies, some thymic B cells;
  • CD3: Pan T cell antigen
  • CD4: Subset of T cells, most T helper cells and normal thymocytes
  • CD5: Pan T cell antigen
  • CD7: T cell leukemia and myeloid leukemia, T cells
  • CD8: Subset of T cells, most T-cytotoxic and T-supressor cells
  • CD10: CALLA, germinal center B cells
  • CD15: Hodgkin lymphoma, granulocytes
  • CD20: Pan B cell antigen
  • CD23: CLL/SLL, low affinity IgE receptor
  • CD30: Hodgkin lymphoma, activated lymphocytes
  • CD34: Blasts, endothelial cells, GIST, DFSP, subset of sarcomas
  • CD38: Multiple myeloma, ALL (B&T) and some AML
  • CD43: T cell, B cell subset, myeloid cells, histiocytes
  • CD45: Leukocyte common antigen
  • CD68: Monocytes, macrophages and subset of sarcomas
  • CD79a: Pan B cell marker
  • CD99: Ewing sarcoma, PNET, lymphoblastic lymphoma/leukemia, diffuse large B cell lymphoma
  • CD138: B cell precursors, plasma cells and their neoplasms
  • CEA: Carcinoembryonic antigen
  • Chromogranin: Neuroendocrine marker
  • CK7: Cytokeratin
  • CK20: Cytokeratin
  • CK34: BE12 High molecular weight cytokeratin
  • Cyclin: D1 Mantle cell lymphoma (BCL-1)
  • Desmin: Muscle marker
  • EGFR: Epidermal growth factor receptor
  • EMA: Epithelial membrane antigen
  • GFAP: Glial acidic fibrillary protein
  • Hepatocyte specific: Normal and neoplastic liver cells antigen
  • Hep Par: Hepatocyte specific antigen
  • HMB-45: Anti-melanosome
  • Kappa Kappa Ig: light chain
  • Ki-67: Proliferation marker
  • Lambda Lambda Ig: light chain
  • MART-1: Melanocyte differentiation antigen
  • P504S: Alpha methylacyl CoA racemase
  • Pax-5: Pro-, pre- and mature B cells, not plasma cells
  • PSA: Prostate specific antigen
  • P504S: Alpha-methylacyl -COA racemase
  • RCC: Renal cell carcinoma
  • S-100: Neural, melanocyte marker
  • Smooth muscle actin: Smooth muscle marker
  • Synaptophysin: Neuroendocrine marker
  • TdT: Acute lymphoblastic/ lymphoma/leukemia
  • TTF-1: Thyroid transcription factor -1
  • Thyroglobulin: Thyroid
  • Vimentin: Mesenchymal marker
  • CD117 (c-Kit): Gastrointestinal stromal tumor (performed at US Labs ***)